he Hitchhiker’s Guide to the Biomolecular Galaxy 2016
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Official Program

Note: All talks will be in ARMS 1010 (See on google maps)

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May 10

  5:30 PM –   7:30 PM     Career Session (Lafayette Brewing Company - second floor)

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May 11

    
8:00 AM – 9:20 AM  

Breakfast, Check-in and Posters Displayed

9:20 AM – 9:30 AM  

Opening Remarks by Satarupa Bhaduri

   

Session 1: Disease, Pathogenesis and Therapeutics

9:30 AM – 9:50 AM  

Nicole M Hjortland

(Graduate student in Department of Biological Sciences, Purdue University)

Decoupling the allosteric activation of ubiquitin specific protease 7 by its ubiquitin-like domains for the development of small molecule inhibitors

9:50 AM – 10:10 AM 

Basudev Chowdhury

(Post-doctoral scholar in Medicinal Chemistry and Molecular Pharmacology, Purdue University

PBRM1 regulates the transcription of genes linked to cell adhesion in renal cell carcinoma

10:10 AM – 10:30 AM   

Shankar Thangamani

(Graduate student in Department of Comparative Pathobiology, Purdue University)

Repurposing auranofin, an FDA approved anti-rheumatic drug, for the treatment of staphylococcal infections
10:30 AM – 10:50 AM 

Yu-Chen Yen

(Graduate student in Department of Biological Sciences, Purdue University)

Structure-based drug design for selective inhibitors against the BACE protein family for the treatment of Alzheimer’s disease and Type II Diabetes

10:50 AM – 11:10 AM    Coffee Break
   

Session 2: Macromolecular Complexes and Assemblies

11:10 AM – 11:30 AM  

Matthew L. Wohlever

(Post-doctoral scholar in Department of Biochemistry and Molecular Biology, University of Chicago)

Quality control of mitochondrial tail-anchored proteins

11:30 AM – 11:50 AM 

Manish Nepal 

(Graduate student in Department of Chemistry , Purdue University)

Promoting metal-assisted hierarchal assembly in coiled coil peptides

11:50 AM – 12:10 PM

Saeed S. Akhand

(Graduate Student in Medicinal Chemistry and Molecular Pharmacology, Purdue University)

Covalent inhibition of FGFR overcomes metastatic resistance to Her2 targeted therapies in breast cancer

12:10 PM – 12:30 PM   

Jeremy Bakelar

(Post-doctoral scholar in Department of Biological Sciences, Purdue University)

Structural analysis of the E.coli beta-barrel assembly machinery complex

12:30 PM – 1:30 PMLunch & Talks
12:45 pm - 1:05 pm

Ed Pryor - Anatrace

High-Output Methods for Protein Crystallization

1:05 pm - 1:20 pm

Dean Clodfelter - Beckman/Coulter

Analytical Ultracentrifuge Technology (AUC): An under-utilized technique for determining the aggregation state of proteins

Session 3: Disorder and Conformational Plasticity in Macromolecules
1:30 PM –  1:50 PM  

Nathan Gardner

(Graduate student in Medicinal Chemistry and Molecular Pharmacology\PULSe, Purdue University)

The structure of an E. coli phosphoglycerate mutase intermediate reveals a physical basis for cooperativity between ligand binding and dimerization

1:50 PM –  2:10 PM 

Yan Zhang

(Post-doctoral scholar in Life Sciences Institute,University of Michigan)

2.8-angstrom cryo-EM structure of the large ribosomal subunit from the parasite Leishmania

2:10 PM –  2:30 PM

Chao Feng

(Graduate student in Medicinal Chemistry and Molecular Pharmacology, Purdue University)

Entropy dominates the allosteric regulation of Syk release from immunoreceptor tyrosine activation motifs
2:30 PM–  2:50 PM

Jennifer N. Cash

(Post-doctoral scholar in Department of Pharmacology, University of Michigan)

Structural and functional characterization of the metastatic rhoGEF P-Rex1 and its regulation by Ptdins(3,4,5)P3: towards inhibitory small molecule development

2:50 PM – 3:10 PM    Coffee Break
 Session 4: Biosynthesis and Catalysis
3:10 PM – 3:30 PM  

Haroon Mohammad

(Graduate student in Department of Comparative Pathobiology, Purdue University)

Gut check: Discovery of phenylthiazole antibiotics effective against vancomycin-resistant Enterococci

3:30 PM – 3:50 PM 

Allison Norvil

(Graduate student in Dept. of Biochemistry, Purdue University)

Dnmt3b methylates DNA by a non-cooperative but processive mechanism

3:50 PM – 4:10 PM

Chun-Liang Chen

(Graduate student in Department of Biological Sciences, Purdue University)

Induced fit model of enzyme-substrate recognition: Study of the mevalonate diphosphate decarboxylase from Enterococcus faecalis

4:10 PM – 4:30 PM   

Christopher J. Petell

(Graduate student in Department of Biochemistry, Purdue University)

An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiantion

4:30 PM – 6:30 PM

Poster Session and Reception:

Food and drink while supply last
7:00 PM

Networking Event:

Stacked Pickle - 516 Northwestern. Ave.

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May 12

8:30 AM – 9:30 AMBreakfast
 Session 5: Computational Biology (Chair: Valentyn Stadnytskyi)
9:30 AM – 9:50 AM  

Duy P. Hua

(Graduate Student in Medicinal Chemistry and Molecular Pharmacology, Purdue University)

Unique allosteric mechanism regulating protein-protein interaction through phosphorylation: a case study of the conformational changes in the Syk tandem SH2 protein

9:50 AM – 10:10 AM 

Lenna X. Peterson

(Graduate student in Department of Biological Sciences, Purdue University)

IDR-LZerD: structure prediction of disordered protein interactions

10:10 AM – 10:30 AM

Genki Terashi

(Visiting scholar in Department of Biological Sciences, Purdue University)

An automated C tracing from cryo-EM map

10:30 AM – 10:50 AM   

Ying Yang

(Graduate Student in Medicinal Chemistry and Molecular Pharmacology, Purdue University)

Dissecting the influence of protein flexibility on the location and thermodynamic profile of explicit water molecules in protein-ligand binding

10:50 AM – 11:10 AM    Coffee Break
11:10 AM – 12:20 PMKeynote Presentation: Peter Kwong (NIAID NIH)
Multi-dimensional searching and coordinates of effective vaccines for HIV-1 and RSV
12:20 PM – 1:20 PMLunch & Talks
12:35 PM - 12:55 PMIssa Isaac - Molecular Dimensions
Protein Crystallography: Cell Culture to Beamline
12:55 PM - 1:10 PMAndy Mesecar - Purdue University
 Session 6: Virus Structure and Infection (Chair: Samantha Lee)
1:20 PM – 1:40 PM  

Devika Sirohi

(Graduate student in Department of Biological Sciences, Purdue University)

The cryo-EM structure of the Zika virus

1:40 PM – 2:00 PM 

Haley Hoover

(Graduate student in Department of Molecular and Cellular Biochemistry, Indiana University)

Host post-translational modification of the brome mosaic virus capsid regulates the timing of viral infection

2:00 PM – 2:20 PM

Vidya Mangala Prasad

(Post-doctoral scholar in Department of Biological Sciences, Purdue University)

Organization of rubella virus structural proteins using cryo-electron tomography

2:20 PM – 2:40 PM   

Ranjan Sengupta

(Post-doctoral scholar in Department of Biological Sciences, Purdue University)

From sheets to vesicles; alphavirus steals a page out of the organelle biogenesis handbook of the cell

2:40 PM – 3:10 PMClosing Remarks, Awards, and Acknowledgements