Official Program
Note: All talks will be in ARMS 1010 (See on google maps)
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May 10
5:30 PM – 7:30 PM Career Session (Lafayette Brewing Company - second floor)
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May 11
8:00 AM – 9:20 AM |
Breakfast, Check-in and Posters Displayed |
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9:20 AM – 9:30 AM |
Opening Remarks by Satarupa Bhaduri |
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Session 1: Disease, Pathogenesis and Therapeutics |
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9:30 AM – 9:50 AM |
Nicole M Hjortland (Graduate student in Department of Biological Sciences, Purdue University) |
Decoupling the allosteric activation of ubiquitin specific protease 7 by its ubiquitin-like domains for the development of small molecule inhibitors |
9:50 AM – 10:10 AM |
Basudev Chowdhury (Post-doctoral scholar in Medicinal Chemistry and Molecular Pharmacology, Purdue University |
PBRM1 regulates the transcription of genes linked to cell adhesion in renal cell carcinoma |
10:10 AM – 10:30 AM |
Shankar Thangamani (Graduate student in Department of Comparative Pathobiology, Purdue University) |
Repurposing auranofin, an FDA approved anti-rheumatic drug, for the treatment of staphylococcal infections |
10:30 AM – 10:50 AM |
Yu-Chen Yen (Graduate student in Department of Biological Sciences, Purdue University) |
Structure-based drug design for selective inhibitors against the BACE protein family for the treatment of Alzheimer’s disease and Type II Diabetes |
10:50 AM – 11:10 AM | Coffee Break | |
Session 2: Macromolecular Complexes and Assemblies |
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11:10 AM – 11:30 AM |
Matthew L. Wohlever (Post-doctoral scholar in Department of Biochemistry and Molecular Biology, University of Chicago) |
Quality control of mitochondrial tail-anchored proteins |
11:30 AM – 11:50 AM |
Manish Nepal (Graduate student in Department of Chemistry , Purdue University) |
Promoting metal-assisted hierarchal assembly in coiled coil peptides |
11:50 AM – 12:10 PM |
Saeed S. Akhand (Graduate Student in Medicinal Chemistry and Molecular Pharmacology, Purdue University) |
Covalent inhibition of FGFR overcomes metastatic resistance to Her2 targeted therapies in breast cancer |
12:10 PM – 12:30 PM |
Jeremy Bakelar (Post-doctoral scholar in Department of Biological Sciences, Purdue University) |
Structural analysis of the E.coli beta-barrel assembly machinery complex |
12:30 PM – 1:30 PM | Lunch & Talks | |
12:45 pm - 1:05 pm |
Ed Pryor - Anatrace High-Output Methods for Protein Crystallization |
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1:05 pm - 1:20 pm |
Dean Clodfelter - Beckman/Coulter Analytical Ultracentrifuge Technology (AUC): An under-utilized technique for determining the aggregation state of proteins |
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Session 3: Disorder and Conformational Plasticity in Macromolecules | ||
1:30 PM – 1:50 PM |
Nathan Gardner (Graduate student in Medicinal Chemistry and Molecular Pharmacology\PULSe, Purdue University) |
The structure of an E. coli phosphoglycerate mutase intermediate reveals a physical basis for cooperativity between ligand binding and dimerization |
1:50 PM – 2:10 PM |
Yan Zhang (Post-doctoral scholar in Life Sciences Institute,University of Michigan) |
2.8-angstrom cryo-EM structure of the large ribosomal subunit from the parasite Leishmania |
2:10 PM – 2:30 PM |
Chao Feng (Graduate student in Medicinal Chemistry and Molecular Pharmacology, Purdue University) |
Entropy dominates the allosteric regulation of Syk release from immunoreceptor tyrosine activation motifs |
2:30 PM– 2:50 PM |
Jennifer N. Cash (Post-doctoral scholar in Department of Pharmacology, University of Michigan) |
Structural and functional characterization of the metastatic rhoGEF P-Rex1 and its regulation by Ptdins(3,4,5)P3: towards inhibitory small molecule development |
2:50 PM – 3:10 PM | Coffee Break | |
Session 4: Biosynthesis and Catalysis | ||
3:10 PM – 3:30 PM |
Haroon Mohammad (Graduate student in Department of Comparative Pathobiology, Purdue University) |
Gut check: Discovery of phenylthiazole antibiotics effective against vancomycin-resistant Enterococci |
3:30 PM – 3:50 PM |
Allison Norvil (Graduate student in Dept. of Biochemistry, Purdue University) |
Dnmt3b methylates DNA by a non-cooperative but processive mechanism |
3:50 PM – 4:10 PM |
Chun-Liang Chen (Graduate student in Department of Biological Sciences, Purdue University) |
Induced fit model of enzyme-substrate recognition: Study of the mevalonate diphosphate decarboxylase from Enterococcus faecalis |
4:10 PM – 4:30 PM |
Christopher J. Petell (Graduate student in Department of Biochemistry, Purdue University) |
An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiantion |
4:30 PM – 6:30 PM |
Poster Session and Reception: Food and drink while supply last |
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7:00 PM |
Networking Event: Stacked Pickle - 516 Northwestern. Ave. |
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May 12
8:30 AM – 9:30 AM | Breakfast | |
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Session 5: Computational Biology (Chair: Valentyn Stadnytskyi) | ||
9:30 AM – 9:50 AM |
Duy P. Hua (Graduate Student in Medicinal Chemistry and Molecular Pharmacology, Purdue University) |
Unique allosteric mechanism regulating protein-protein interaction through phosphorylation: a case study of the conformational changes in the Syk tandem SH2 protein |
9:50 AM – 10:10 AM |
Lenna X. Peterson (Graduate student in Department of Biological Sciences, Purdue University) |
IDR-LZerD: structure prediction of disordered protein interactions |
10:10 AM – 10:30 AM |
Genki Terashi (Visiting scholar in Department of Biological Sciences, Purdue University) |
An automated C tracing from cryo-EM map |
10:30 AM – 10:50 AM |
Ying Yang (Graduate Student in Medicinal Chemistry and Molecular Pharmacology, Purdue University) |
Dissecting the influence of protein flexibility on the location and thermodynamic profile of explicit water molecules in protein-ligand binding |
10:50 AM – 11:10 AM | Coffee Break | |
11:10 AM – 12:20 PM | Keynote Presentation: Peter Kwong (NIAID NIH) Multi-dimensional searching and coordinates of effective vaccines for HIV-1 and RSV |
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12:20 PM – 1:20 PM | Lunch & Talks | |
12:35 PM - 12:55 PM | Issa Isaac - Molecular Dimensions Protein Crystallography: Cell Culture to Beamline |
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12:55 PM - 1:10 PM | Andy Mesecar - Purdue University | |
Session 6: Virus Structure and Infection (Chair: Samantha Lee) | ||
1:20 PM – 1:40 PM |
Devika Sirohi (Graduate student in Department of Biological Sciences, Purdue University) |
The cryo-EM structure of the Zika virus |
1:40 PM – 2:00 PM |
Haley Hoover (Graduate student in Department of Molecular and Cellular Biochemistry, Indiana University) |
Host post-translational modification of the brome mosaic virus capsid regulates the timing of viral infection |
2:00 PM – 2:20 PM |
Vidya Mangala Prasad (Post-doctoral scholar in Department of Biological Sciences, Purdue University) |
Organization of rubella virus structural proteins using cryo-electron tomography |
2:20 PM – 2:40 PM |
Ranjan Sengupta (Post-doctoral scholar in Department of Biological Sciences, Purdue University) |
From sheets to vesicles; alphavirus steals a page out of the organelle biogenesis handbook of the cell |
2:40 PM – 3:10 PM | Closing Remarks, Awards, and Acknowledgements | |